The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders : a hypothesis paper

Gillberg, C, Fernell, E, Kočovská, E, Minnis, H, Bourgeron, T, Thompson, L and Allely, CS 2017, 'The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders : a hypothesis paper' , Autism Research .

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Abstract

Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the “autisms” [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as “steroid metabolism” and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. Autism Res 2017. © 2017 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research.

Item Type: Article
Schools: Schools > School of Health Sciences > Centre for Health Sciences Research
Journal or Publication Title: Autism Research
Publisher: Wiley Online Library
Related URLs:
Depositing User: CS Allely
Date Deposited: 05 May 2017 09:51
Last Modified: 08 Aug 2017 12:38
URI: http://usir.salford.ac.uk/id/eprint/41541

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