Eosinophils are key regulators of perivascular adipose tissue and vascular functionality

Withers, SB, Forman, R, Meza-Perez, S, Sorobetea, D, Sitnik, K, Hopwood, T, Lawrence, CB, Agace, WW, Else, KJ, Heagerty, AM, Svensson-Fre, M and Cruickshank, SM 2017, 'Eosinophils are key regulators of perivascular adipose tissue and vascular functionality' , Scientific Reports .

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution 4.0.

Download (1MB) | Preview

Abstract

Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension and impaired glucose intolerance. Resident immune cells are thought to regulate adipocyte activity. We investigated the role of eosinophils in mediating normal PVAT function. Healthy PVAT elicits an anti-contractile effect, which was lost in mice deficient in eosinophils, mimicking the obese phenotype, and was restored upon eosinophil reconstitution. Ex vivo studies demonstrated that the loss of PVAT function was due to reduced bioavailability of adiponectin and adipocyte-derived nitric oxide, which was restored after eosinophil reconstitution. Mechanistic studies demonstrated that adiponectin and nitric oxide are released after activation of adipocyte-expressed β3 adrenoceptors by catecholamines, and identified eosinophils as a novel source of these mediators. We conclude that adipose tissue eosinophils play a key role in the regulation of normal PVAT anti-contractile function.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group
ISSN: 2045-2322
Related URLs:
Funders: Wellcome Trust
Depositing User: Sarah Withers
Date Deposited: 20 Mar 2017 16:11
Last Modified: 09 Aug 2017 06:37
URI: http://usir.salford.ac.uk/id/eprint/41640

Actions (login required)

Edit record (repository staff only) Edit record (repository staff only)

Downloads

Downloads per month over past year