High intensity focused ultrasound in the treatment of breast fibroadenomata (HIFU-F trial)

Peek, MCL, Ahmed, M, Scudder, J, Baker, RD, Charalampoudis, P, Pinder, SE and Douek, M 2017, 'High intensity focused ultrasound in the treatment of breast fibroadenomata (HIFU-F trial)' , International Journal of Hyperthermia , pp. 1-23.

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Abstract

Background: High intensity focused ultrasound (HIFU) is a non-invasive ablative technique utilising the application of high frequency ultrasound (US) pressure waves to cause tissue necrosis. This emerging technology is currently limited by prolonged treatment times. The aim of the HIFU-F trial was to perform circumferential HIFU treatment as a means of shortening treatment times. Methods: A prospective trial was set up to treat 50 consecutive patients ≥18 years of age. Eligible patients possessed symptomatic fibroadenomata, visible on US. Patients ≥25 years of age required histological confirmation of the diagnosis. Primary outcome measures were reduction in treatment time, reduction in volume on US after 12 months and complication rates. Results: HIFU treatment was performed in 51 patients (53 treatments) with a mean age of 29.8 years (SD 7.2 years) and diameter of 2.6 cm (SD 1.4 cm). Circumferential ablation reduced treatment times by an estimated 19.9 minutes (SD 25.1 minutes), which is a 29.4% (SD 15.2%) reduction compared to whole lesion ablation. Volume reduction of 43.2% (SD 35.4%; p<0.005, paired t-test) was observed on US at 12 months post-treatment. Local complications completely resolved at one month apart from skin hyper-pigmentation, which persisted in nine cases at three months, six cases at six months and six at 12 months. Conclusion: Circumferential HIFU treatment for breast fibroadenomata is feasible to reduce both lesion size and treatment time. HIFU is a non-invasive alternative technique for the treatment of breast fibroadenomata.

Item Type: Article
Schools: Schools > Salford Business School
Journal or Publication Title: International Journal of Hyperthermia
Publisher: Taylor and Francis
ISSN: 0265-6736
Related URLs:
Depositing User: Prof Rose Dawn Baker
Date Deposited: 04 Sep 2017 11:33
Last Modified: 05 Sep 2017 02:02
URI: http://usir.salford.ac.uk/id/eprint/43666

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