Effects of hypoxia during continuous and intermittent exercise on glycemic control and selected markers of vascular function in Type I Diabetics

Hall, B, Zebrowska, A, Kaminski, T, Stanula, A and Robins, A 2017, 'Effects of hypoxia during continuous and intermittent exercise on glycemic control and selected markers of vascular function in Type I Diabetics' , Experimental and Clinical Endocrinology and Diabetes .

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Abstract

Objectives : The aim of the study was to assess the effect of continuous and intermittent exercise in hypoxia on glycaemic control and selected markers of vascular function in patients with Type 1 diabetes (T1D). Methods : 12 patients suffering from T1D for 12.1±6.0 years and 12 healthy adults performed: continuous exercise (ExC) and intermittent exercise (ExInt) in normoxia and hypoxia (FiO₂=15.1%). Glycaemia and proangiogenic factors concentrations were measured at rest and immediately after exercise. Results : T1D patients' glycaemia decreased in response to ExC (p<0.01) and ExInt (p<0.05) under hypoxic conditions. ExInt in normoxia (p<0.05) and hypoxia (p<0.05) reduced HIF-1α in the T1D group. A tendency for vascular endothelial growth factor to increase after ExInt in hypoxia (6.0±3.8 vs. 17.1±13.07 pg/mL) and a proinflammatory cytokine TNF-α level to decrease (33.2±19.1 vs. 25.1±14.4 pg/mL) was found in the same group. Conclusions : Combining exercise with hypoxia may allow more effective short-term glycaemic control in T1D. Intermittent exercise with hypoxia could stabilize the secretion of selected proangiogenic factors and reduce inflammation, potentially leading to improved vascular function.

Item Type: Article
Schools: Schools > School of Health Sciences > Centre for Health Sciences Research
Journal or Publication Title: Experimental and Clinical Endocrinology and Diabetes
Publisher: Thieme
ISSN: 0947-7349
Related URLs:
Depositing User: Dr Anna Robins
Date Deposited: 20 Nov 2017 12:03
Last Modified: 20 Nov 2017 12:31
URI: http://usir.salford.ac.uk/id/eprint/44113

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