Mitochondrial fission as a driver of stemness in tumor cells : mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling

Peiris-Pagès, M, Bonuccelli, G, Sotgia, F and Lisanti, MP 2018, 'Mitochondrial fission as a driver of stemness in tumor cells : mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling' , Oncotarget, 9 (17) , pp. 13254-13275.

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Abstract

Mitochondria are dynamic organelles frequently undergoing fission and fusion events to maintain their integrity, bioenergetics and spatial distribution, which is fundamental to the processes of cell survival. Disruption in mitochondrial dynamics plays a role in cancer. Therefore, proteins involved in regulating mitochondrial dynamics are potential targets for treatment. mDIVI1 is an inhibitor of the mitochondrial fission protein DRP1, which induces i) mitochondrial oxidative stress and ii) effectively reduces mitochondrial metabolism. We show here that mDIVI1 is able to inhibit 3D tumorsphere forming capacity, cell migration and stemness-related signalling in breast cancer cells, indicating that mDIVI1 can potentially be used for the therapeutic elimination of cancer stem cells (CSCs).

Item Type: Article
Uncontrolled Keywords: OXPHOS, cancer stem-like cells (CSCs), cell migration, metastasis, mitochondrial fission
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Oncotarget
Publisher: Impact Journals
ISSN: 1949-2553
Related URLs:
Funders: University of Manchester, British Schools and Universities Foundation, Healthy Life Foundation (HLF), Foxpoint Foundation
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 03 Apr 2018 09:31
Last Modified: 03 Apr 2018 14:02
URI: http://usir.salford.ac.uk/id/eprint/46512

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