Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents

Ragazzon, PA, McGown, A, Ragazzon-Smith, AH, Hadfield, JA and Potgetier, H 2018, 'Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents' , Letters in Organic Chemistry, 15 .

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Abstract

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 µM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Letters in Organic Chemistry
Publisher: Bentham Science
ISSN: 1570-1786
Related URLs:
Funders: University of Salford
Depositing User: JA Hadfield
Date Deposited: 26 Jun 2018 10:34
Last Modified: 26 Jun 2018 17:42
URI: http://usir.salford.ac.uk/id/eprint/47480

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