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Detection of high levels of congenital transmission of toxoplasma gondii in natural urban populations of mus domesticus

Marshall, PA, Hughes, JM, Murphy, G, Williams, RH, Smith, JE, Murphy, RG and Hide, G 2004, 'Detection of high levels of congenital transmission of toxoplasma gondii in natural urban populations of mus domesticus' , Parasitology, 128 (1) , pp. 39-42.

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    Abstract

    The relative importance of different transmission routes of Toxoplasma gondii has been a matter for debate. This ubiquitous parasite is generally thought to be transmitted by infective oocysts excreted by the definitive host, the cat. Ingestion of undercooked meat has also been considered an important route of transmission in many mammals while congenital transmission has generally been considered relatively rare. Experimental studies demonstrate the ability of T. gondii to be transmitted congenitally, but few studies have investigated the frequency of this transmission route in natural populations. We use PCR amplification of the SAG1 gene to investigate the frequency of congenital transmission in a wild population of mice (Mus domesticus) and show that congenital transmission is occurring in 75% of pregnancies in this population. Furthermore, for infected pregnant mice, transmission occurs to at least one foetus in 100% of cases while variable penetrance of congenital infection is observed. These high levels of congenital transmission in this wild population of mice, taken together with other recent data on congenital transmission in sheep, suggests that this phenomenon might be more widespread than previously thought.

    Item Type: Article
    Uncontrolled Keywords: Toxoplasma gondii, mus domesticus, PCR, SAG1, congenital, transmission
    Themes: Subjects / Themes > Q Science > QR Microbiology
    Subjects outside of the University Themes
    Schools: Colleges and Schools > College of Science & Technology
    Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
    Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Ecosystems and Environment Research Centre
    Journal or Publication Title: Parasitology
    Publisher: Cambridge University Press
    Refereed: Yes
    ISSN: 00311820
    Depositing User: H Kenna
    Date Deposited: 05 Oct 2007 13:16
    Last Modified: 20 Aug 2013 16:49
    URI: http://usir.salford.ac.uk/id/eprint/659

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