Skip to the content

Unravelling the moulting degradome: new opportunities for chemotherapy?

Craig, H, Isaac, RE and Brooks, DR 2007, 'Unravelling the moulting degradome: new opportunities for chemotherapy?' , Trends in Parasitology, 23 (6) , pp. 248-253.

[img] PDF - Published Version
Restricted to Repository staff only

Download (327kB) | Request a copy

    Abstract

    Replacement of the nematode cuticle with a newly synthesized cuticle (a process known as moulting) occurs four times during larval development. Therefore, the key components of this essential developmental process represent attractive targets for new chemotherapeutic strategies. Recent advances in understanding the molecular genetics of nematode moulting should stimulate and facilitate development of novel drugs that target the essential molecules of the moulting cycle. In particular, we argue that further understanding of the moulting degradome and its key peptidase members offers an important opportunity for the development of novel antinematode agents.

    Item Type: Article
    Contributors: (Author) and (Author)
    Themes: Subjects / Themes > Q Science > QH Natural history > QH301 Biology
    Subjects outside of the University Themes
    Schools: Colleges and Schools > College of Science & Technology
    Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
    Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Biomedical Research Centre
    Journal or Publication Title: Trends in Parasitology
    Publisher: Elsevier
    Refereed: Yes
    ISSN: 1471-4922
    Funders: Biotechnology and Biosciences Sciences Research Council (BBSRC)
    Depositing User: DR Brooks
    Date Deposited: 10 Sep 2010 11:38
    Last Modified: 13 Jan 2014 10:15
    URI: http://usir.salford.ac.uk/id/eprint/9680

    Actions (login required)

    Edit record (repository staff only)

    Downloads per month over past year

    View more statistics