Unravelling the moulting degradome: new opportunities for chemotherapy?
Craig, H, Isaac, RE and Brooks, DR 2007, 'Unravelling the moulting degradome: new opportunities for chemotherapy? ' , Trends in Parasitology, 23 (6) , pp. 248-253.
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Replacement of the nematode cuticle with a newly synthesized cuticle (a process known as moulting) occurs four times during larval development. Therefore, the key components of this essential developmental process represent attractive targets for new chemotherapeutic strategies. Recent advances in understanding the molecular genetics of nematode moulting should stimulate and facilitate development of novel drugs that target the essential molecules of the moulting cycle. In particular, we argue that further understanding of the moulting degradome and its key peptidase members offers an important opportunity for the development of novel antinematode agents.
|Contributors:||(Author) and (Author)|
|Themes:||Subjects / Themes > Q Science > QH Natural history > QH301 Biology|
Subjects outside of the University Themes
|Schools:||Colleges and Schools > College of Science & Technology|
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Biomedical Research Centre
|Journal or Publication Title:||Trends in Parasitology|
|Funders:||Biotechnology and Biosciences Sciences Research Council (BBSRC)|
|Depositing User:||DR Brooks|
|Date Deposited:||10 Sep 2010 11:38|
|Last Modified:||13 Jan 2014 10:15|
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