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Unravelling the moulting degradome: new opportunities for chemotherapy?

Craig, H, Isaac, RE and Brooks, DR 2007, 'Unravelling the moulting degradome: new opportunities for chemotherapy?' , Trends in Parasitology, 23 (6) , pp. 248-253.

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Abstract

Replacement of the nematode cuticle with a newly synthesized cuticle (a process known as moulting) occurs four times during larval development. Therefore, the key components of this essential developmental process represent attractive targets for new chemotherapeutic strategies. Recent advances in understanding the molecular genetics of nematode moulting should stimulate and facilitate development of novel drugs that target the essential molecules of the moulting cycle. In particular, we argue that further understanding of the moulting degradome and its key peptidase members offers an important opportunity for the development of novel antinematode agents.

Item Type: Article
Contributors: (Author) and (Author)
Themes: Subjects / Themes > Q Science > QH Natural history > QH301 Biology
Subjects outside of the University Themes
Schools: Colleges and Schools > College of Science & Technology
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Trends in Parasitology
Publisher: Elsevier
Refereed: Yes
ISSN: 1471-4922
Funders: Biotechnology and Biosciences Sciences Research Council (BBSRC)
Depositing User: DR Brooks
Date Deposited: 10 Sep 2010 10:38
Last Modified: 13 Jan 2014 10:15
URI: http://usir.salford.ac.uk/id/eprint/9680

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