Davidson, EJ, Faulkner, RL, Sehr, P, Pawlita, M, Smyth, LJC, Burt, DJ, Tomlinson, AE, Hickling, J, Kitchener, HC and Stern, PL 2004, 'Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7)' , Vaccine, 22 (21-22) , pp. 2722-2729.
Full text not available from this repository. (Request a copy)Abstract
Heterologous prime-boost vaccination schedules employing TA-HPV, a vaccinia virus encoding HPV 16/18 E6 and E7, in combination with TA-CIN, an HPV 16 L2E6E7 fusion protein, may offer advantages over the use of either agent alone for the immunotherapy of human papillomavirus (HPV) type 16-associated vulval intraepithelial neoplasia (VIN). In the present study, 10 women with HPV 16-positive high grade VIN, previously primed with TA-HPV, received three booster immunisations with TA-CIN. All but one demonstrated HPV 16-specific proliferative T-cell and/or serological responses following vaccination. Three patients additionally showed lesion shrinkage or symptom relief, but no direct correlation between clinical and immunological responses was seen.
| Item Type: | Article |
|---|---|
| Themes: | Subjects / Themes > Q Science > QR Microbiology Subjects outside of the University Themes |
| Schools: | Schools > School of Environment and Life Sciences |
| Journal or Publication Title: | Vaccine |
| Publisher: | Elsevier |
| Refereed: | Yes |
| ISSN: | 0264410X |
| Depositing User: | Users 29196 not found. |
| Date Deposited: | 23 Dec 2010 14:37 |
| Last Modified: | 27 Aug 2021 22:33 |
| URI: | https://usir.salford.ac.uk/id/eprint/12689 |
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