Assessment of the molecular basis of the proallergenic effects of cigarette smoke

Smyth, LJC, Machado, DC, Upton, AP, Good, S, Aufderheide, M and Helm, BA 2000, 'Assessment of the molecular basis of the proallergenic effects of cigarette smoke' , Environmental Science & Technology, 34 (7) , pp. 1370-1374.

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Epidemiological studies indicate a link between smoking and increased risk of immunoglobulin E-mediated allergies and asthma. The molecular basis underlying cigarette smoke related respiratory disorders are ill defined, but it is known that mast cells in the mucosal lining of the airways are an important reservoir of proinflammatory mediators, which play a pivotal role in the development of these diseases. The establishment of a novel cell exposure unit facilitated a study of mast cell responses to pollutants in mainstream cigarette smoke at the air/cell interface. Our study shows that cigarette smoke, but not filtered clean air, induces the release of mediators of type I hypersensitivity responses and stimulates the synthesis of proinflammatory cytokines, including interleukin (IL)-4, 5, 10, and 13 and tumor necrosis factor (TNF)-α, in cells of mast cell lineage. These results explain how exposure to pollutants present in cigarette smoke can induce the pathophysiological responses associated with allergy, IgE-mediated and IgE-independent asthma since IL-4 and IL-13 induce class switching to IgE, and IL-13 has recently been identified as the key mediator of IgE-independent asthma.

Item Type: Article
Themes: Subjects / Themes > Q Science > QR Microbiology
Subjects outside of the University Themes
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Environmental Science & Technology
Publisher: ACS Publications
Refereed: Yes
ISSN: 0013-936X
Depositing User: Users 29196 not found.
Date Deposited: 23 Dec 2010 14:41
Last Modified: 27 Aug 2021 22:33

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