Synthesis of furano-epothilone D

Schinzer, D, Bourguet, E and Ducki, S 2004, 'Synthesis of furano-epothilone D' , Chemistry - A European Journal, 10 (13) , pp. 3217-3224.

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The total synthesis of furano-epothilone D by a convergent route is reported. The key fragments are available on a large scale to provide sufficient material for biological evaluation. The approach involves a palladium-catalyzed coupling that generates a highly functionalized aldehyde which is connected in a stereoselective aldol reaction to yield the framework of furano-epothilone D. Finally, a macrolactonization provides furano-epothilone D.

Item Type: Article
Themes: Subjects / Themes > Q Science > Q Science (General)
Subjects outside of the University Themes
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Chemistry - A European Journal
Publisher: John Wiley & Sons
Refereed: Yes
ISSN: 09476539
Depositing User: H Kenna
Date Deposited: 07 Aug 2007 12:59
Last Modified: 27 Aug 2021 21:58

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