Schinzer, D, Bourguet, E and Ducki, S 2004, 'Synthesis of furano-epothilone D' , Chemistry - A European Journal, 10 (13) , pp. 3217-3224.
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Official URL: http://dx.doi.org/10.1002/chem.200400125
Abstract
The total synthesis of furano-epothilone D by a convergent route is reported. The key fragments are available on a large scale to provide sufficient material for biological evaluation. The approach involves a palladium-catalyzed coupling that generates a highly functionalized aldehyde which is connected in a stereoselective aldol reaction to yield the framework of furano-epothilone D. Finally, a macrolactonization provides furano-epothilone D.
| Item Type: | Article |
|---|---|
| Themes: | Subjects / Themes > Q Science > Q Science (General) Subjects outside of the University Themes |
| Schools: | Schools > School of Environment and Life Sciences |
| Journal or Publication Title: | Chemistry - A European Journal |
| Publisher: | John Wiley & Sons |
| Refereed: | Yes |
| ISSN: | 09476539 |
| Depositing User: | H Kenna |
| Date Deposited: | 07 Aug 2007 12:59 |
| Last Modified: | 27 Aug 2021 21:58 |
| URI: | https://usir.salford.ac.uk/id/eprint/141 |
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