Chiang, GCH, Ayscough, A, Bond, AD, Pain, G, Ducki, S and Holmes, AB 2005, 'Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy' , Chemical Communications (14) , pp. 1860-1862.
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Official URL: http://dx.doi.org/10.1039/b413426e
Abstract
The enantioselective synthesis of a simplified eleutherobin analogue by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin is described; the analogue and an advanced intermediate revealed microtubule stabilising properties in the micromolar range.
| Item Type: | Article |
|---|---|
| Themes: | Subjects / Themes > Q Science > Q Science (General) Subjects / Themes > Q Science > QD Chemistry Subjects outside of the University Themes |
| Schools: | Schools > School of Environment and Life Sciences |
| Journal or Publication Title: | Chemical Communications |
| Publisher: | Royal Society of Chemistry |
| Refereed: | Yes |
| ISSN: | 13597345 |
| Depositing User: | H Kenna |
| Date Deposited: | 07 Aug 2007 13:02 |
| Last Modified: | 01 Dec 2015 00:01 |
| URI: | http://usir.salford.ac.uk/id/eprint/142 |
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