Chiang, GCH, Ayscough, A, Bond, AD, Pain, G, Ducki, S and Holmes, AB 2005, 'Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy' , Chemical Communications (14) , pp. 1860-1862.
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Official URL: http://dx.doi.org/10.1039/b413426e
Abstract
The enantioselective synthesis of a simplified eleutherobin analogue by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin is described; the analogue and an advanced intermediate revealed microtubule stabilising properties in the micromolar range.
Item Type: | Article |
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Themes: | Subjects / Themes > Q Science > Q Science (General) Subjects / Themes > Q Science > QD Chemistry Subjects outside of the University Themes |
Schools: | Schools > School of Environment and Life Sciences |
Journal or Publication Title: | Chemical Communications |
Publisher: | Royal Society of Chemistry |
Refereed: | Yes |
ISSN: | 13597345 |
Depositing User: | H Kenna |
Date Deposited: | 07 Aug 2007 13:02 |
Last Modified: | 27 Aug 2021 21:58 |
URI: | https://usir.salford.ac.uk/id/eprint/142 |
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