Foster, HA and Elgalai, I 2003, 'Comparison of adhesion of wound isolates of Staphylococcus aureus to immobilized proteins' , Journal of Applied Microbiology, 94 (3) , pp. 413-420.
Full text not available from this repository. (Request a copy)Abstract
Aims: To determine the ability of 149 clinical isolates of Staphylococcus aureus from burns, other wounds and environmental isolates to adhere to immobilized proteins. Methods and Results: The ability to bind to immobilized fibrinogen, fibronectin, laminin, collagen, IgG and lysozyme was studied using a microtitre plate assay. The strains were very diverse. Binding to fibrinogen was most frequent, followed by fibronectin, collagen and laminin. Binding to IgG and lysozyme was weak and few strains showed strong binding. Numerical analysis showed that 65% of the strains infecting burns had similar properties and bound to fibrinogen, fibronectin, collagen and IgG. The strains infecting other wounds had more variable characteristics. Conclusions: The ability to adhere to proteins is important in wound infection, but clinical isolates were diverse in their ability to bind to the proteins tested. Burn wounds were more likely to be infected with strains showing multiple binding characteristics. Significance and Impact of the study: The study confirms the importance of adhesins in clinical infection.
| Item Type: | Article |
|---|---|
| Themes: | Subjects / Themes > Q Science > Q Science (General) Subjects / Themes > R Medicine > R Medicine (General) Subjects / Themes > Q Science > QR Microbiology Health and Wellbeing Subjects outside of the University Themes |
| Schools: | Schools > School of Environment and Life Sciences Schools > School of Environment and Life Sciences > Ecosystems and Environment Research Centre |
| Journal or Publication Title: | Journal of Applied Microbiology |
| Publisher: | Blackwell Publishing |
| Refereed: | Yes |
| ISSN: | 13645072 |
| Depositing User: | H Kenna |
| Date Deposited: | 07 Aug 2007 13:10 |
| Last Modified: | 27 Aug 2021 21:58 |
| URI: | https://usir.salford.ac.uk/id/eprint/145 |
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