Hadfield, JA, Gaukroger, K, Hirst, N, Weston, AP, Lawrence, NJ and McGown, AT 2005, 'Synthesis and evaluation of double bond substituted combretastatins' , European Journal of Medicinal Chemistry, 40 (6) , pp. 529-541.
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Abstract
A series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Combretastatin; Tubulin; Antimitotic |
| Themes: | Subjects / Themes > Q Science > Q Science (General) Subjects / Themes > Q Science > QD Chemistry Subjects outside of the University Themes |
| Schools: | Schools > School of Environment and Life Sciences Schools > School of Environment and Life Sciences > Biomedical Research Centre |
| Journal or Publication Title: | European Journal of Medicinal Chemistry |
| Publisher: | Elsevier |
| Refereed: | Yes |
| ISSN: | 02235234 |
| Depositing User: | H Kenna |
| Date Deposited: | 07 Aug 2007 13:57 |
| Last Modified: | 01 Dec 2015 00:01 |
| URI: | http://usir.salford.ac.uk/id/eprint/151 |
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