Ruparelia, P, Cheow, HK, Evans, JW, Banney, L, Shankar, S, Szczepura, K ORCID: https://orcid.org/0000-0002-2566-3308, Swift, AE, Ballinger, JR, Hartman, NG, Chilvers, ER and Peters, AM
2008,
'Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers'
, British Journal of Clinical Pharmacology, 65 (4)
, pp. 611-614.
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Abstract
Aim - To explore inhaled technetium-99m-labelled hexakis-methoxy-isobutyl isonitrile (99mTc-sestamibi) for quantifying pulmonary P-glycoprotein(P-gp) expression. Methods - The elimination rate from the lungs of 99mTc-sestamibi was recorded scintigraphically for 30min following inhalation as an aerosol in healthy smokers, nonsmokers and patients with lung disease. Results - 99m Tc-sestamibi elimination rates [%min-1 (SD; P vs. healthy nonsmokers)] were: healthy nonsmokers, 0.43 (0.083); healthy smokers,0.19 (0.056; P < 0.001); chronic obstructive pulmonary disease patients, 0.26 (0.077; P < 0.001). Elimination rates in three patients with interstitial lung disease were not accelerated. Cconclusion - Cigarette smoke upregulates lung P-gp. 99mTc-sestamibi elimination in normal smokers could be used to test new P-gp modulators. The findings also have implications for inhaled drug delivery.
Item Type: | Article |
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Themes: | Health and Wellbeing |
Schools: | Schools > School of Health Sciences |
Journal or Publication Title: | British Journal of Clinical Pharmacology |
Publisher: | Wiley-Blackwell |
Refereed: | Yes |
ISSN: | 0306-5251 |
Depositing User: | RH Shuttleworth |
Date Deposited: | 16 May 2011 10:25 |
Last Modified: | 17 Jan 2018 16:03 |
URI: | http://usir.salford.ac.uk/id/eprint/15791 |
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