Burr, SJ, Mselati, A and Thomas, EW 2003, 'Photochemical DNA cleavage by a Berenil analog' , Tetrahedron Letters, 44 (39) , pp. 7307-7309.
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Official URL: http://dx.doi.org/10.1016/j.tetlet.2003.08.002
Abstract
Berenil [bis(4-amidinophenyl)1,3-triazene] is a photostable DNA-binding ligand. We describe here the synthesis of N-(3-hydroxypropyl)-Berenil, which in contrast to Berenil is photosensitive to 360 nm irradiation, behaving as a caged diazonium salt. The 4-amidinobenzenediazonium fragment produced by photolysis induces DNA modification and cleavage.
| Item Type: | Article |
|---|---|
| Themes: | Subjects / Themes > Q Science > Q Science (General) Subjects outside of the University Themes |
| Schools: | Schools > School of Environment and Life Sciences |
| Journal or Publication Title: | Tetrahedron Letters |
| Publisher: | Elsevier |
| Refereed: | Yes |
| ISSN: | 00404039 |
| Depositing User: | H Kenna |
| Date Deposited: | 08 Aug 2007 12:45 |
| Last Modified: | 27 Aug 2021 21:59 |
| URI: | https://usir.salford.ac.uk/id/eprint/184 |
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