Photochemical DNA cleavage by a Berenil analog

Burr, SJ, Mselati, A and Thomas, EW 2003, 'Photochemical DNA cleavage by a Berenil analog' , Tetrahedron Letters, 44 (39) , pp. 7307-7309.

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Berenil [bis(4-amidinophenyl)1,3-triazene] is a photostable DNA-binding ligand. We describe here the synthesis of N-(3-hydroxypropyl)-Berenil, which in contrast to Berenil is photosensitive to 360 nm irradiation, behaving as a caged diazonium salt. The 4-amidinobenzenediazonium fragment produced by photolysis induces DNA modification and cleavage.

Item Type: Article
Themes: Subjects / Themes > Q Science > Q Science (General)
Subjects outside of the University Themes
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Tetrahedron Letters
Publisher: Elsevier
Refereed: Yes
ISSN: 00404039
Depositing User: H Kenna
Date Deposited: 08 Aug 2007 12:45
Last Modified: 27 Aug 2021 21:59

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