Asymmetric alkylation of diphenylmethane derivatives using (-)-sparteine

Wilkinson, JA ORCID: https://orcid.org/0000-0003-1300-6017, Rossington, SB, Leonard, J and Hussain, N 2004, 'Asymmetric alkylation of diphenylmethane derivatives using (-)-sparteine' , Tetrahedron Letters, 45 (6) , pp. 1191-1193.

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Abstract

Alkylation of 2-oxygenated diphenylmethane derivatives using sec-butyllithium and (−)-sparteine gave enantiomeric excesses of up to 60% with allyl bromide but alkylations with methyl electrophiles were poorly selective. When compounds with a free hydroxy in the 2-position were alkylated the selectivity was reversed.

Item Type:	Article
Themes:	Subjects / Themes > Q Science > Q Science (General) Subjects / Themes > Q Science > QD Chemistry Subjects outside of the University Themes
Schools:	Schools > School of Environment and Life Sciences Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title:	Tetrahedron Letters
Publisher:	Elsevier
Refereed:	Yes
ISSN:	00404039
Depositing User:	H Kenna
Date Deposited:	08 Aug 2007 14:07
Last Modified:	27 Aug 2021 21:59
URI:	http://usir.salford.ac.uk/id/eprint/189

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