Drug-induced supersensitivity psychosis revisited: characteristics of relapse in treatment-compliant patients

Fallon, P, Dursun, S and Deakin, B 2012, 'Drug-induced supersensitivity psychosis revisited: characteristics of relapse in treatment-compliant patients' , Therapeutic Advances in Psychopharmacology, 2 (1) , pp. 13-22.

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Background: An association between abnormal involuntary movements and psychotic relapse was previously reported in a group of patients compliant with antipsychotic medication (Fallon and Dursun 2011). This was interpreted as the presence of an antipsychotic medication-induced supersensitivity psychosis. Method: From the results of that study and the Chouinard diagnostic criteria for supersensitivity psychosis an abbreviated diagnostic checklist was developed to identify the phenomenon. In the present study the checklist was used on a larger sample of medication-compliant individuals experiencing a psychotic relapse. Results: The checklist demonstrated its utility by identifying a cause of relapse in 70% (29/41) of patients. Furthermore, it identified the presence of supersensitivity psychosis in 39% (16/41) of patients. This study also replicated a number of findings from the previous paper supporting the idea that supersensitivity psychosis is one cause of relapse in psychosis. Discussion: These results suggested that clinicians should exercise caution in prescribing and may have to augment treatment with other agents or switch to low dopamine-affinity antipsychotics.

Item Type: Article
Themes: Health and Wellbeing
Schools: Schools > School of Health and Society > Centre for Applied Research in Health, Welfare and Policy
Schools > School of Health and Society
Journal or Publication Title: Therapeutic Advances in Psychopharmacology
Publisher: Sage Publications
Refereed: Yes
ISSN: 2045-1253
Depositing User: H Kenna
Date Deposited: 08 Oct 2012 13:30
Last Modified: 16 Feb 2022 14:35
URI: https://usir.salford.ac.uk/id/eprint/26996

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