The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa

Fothergill, J, Mowat, E, Walshaw, M, Ledson, M, James, C ORCID: https://orcid.org/0000-0002-0131-7988 and Winstanley, C 2011, 'The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa' , Antimicrobial Agents in Chemotherapy, 55 (1) , pp. 426-428.

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Abstract

Phage production in response to antibiotics varied among four isolates of a Pseudomonas aeruginosa cystic fibrosis (CF) epidemic strain. Whereas ciprofloxacin induced higher levels of phage production, other CF-relevant antibiotics led to reduced production. We detected free phages directly in CF patient sputum samples by both plaque (40% positive) and PCR (76% positive) assays. Our observations suggest that the choice of antibiotics could influence the number of free phages within the CF lung environment

Item Type:	Article
Themes:	Health and Wellbeing
Schools:	Schools > School of Environment and Life Sciences > Biomedical Research Centre Schools > School of Environment and Life Sciences
Journal or Publication Title:	Antimicrobial Agents in Chemotherapy
Publisher:	American Society for Microbiology
Refereed:	Yes
ISSN:	0066-4804
Related URLs:	Publication
Funders:	The NIHR School for Social Care Research (SSCR), The Dr Hadwen Trust, The Wellcome Trust
Depositing User:	Dr Chloe James
Date Deposited:	21 Mar 2013 16:43
Last Modified:	16 Feb 2022 14:49
URI:	https://usir.salford.ac.uk/id/eprint/28486

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