Model-based scenarios for the epidemiology of HIV/AIDS: the consequences of highly active antiretroviral therapy

Dangerfield, BC, Fang, Y and Roberts, CA 2001, 'Model-based scenarios for the epidemiology of HIV/AIDS: the consequences of highly active antiretroviral therapy' , System Dynamics Review, 17 (2) , pp. 119-150.

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Abstract

A system dynamics model of HIV/AIDS epidemiology is employed to simulate the effects of triple combination antiretroviral therapy in the treatment of HIV/AIDS. The epidemic data on homosexual men in the UK (1981--1998) have been used to fit the baseline model. The new combination therapies, which supplanted antiviral mono and dual therapy in 1996, are proving to be the most effective prophylaxis yet for halting viral replication in vivo, but many uncertainties still surround their use. A range of model-generated scenarios are created as a means of considering these uncertainties. Possible futures for the HIV/AIDS epidemic are constructed.

Item Type:	Article
Themes:	Subjects / Themes > Q Science > QA Mathematics > QA275 Mathematical Statistics Subjects / Themes > H Social Sciences > HA Statistics Subjects outside of the University Themes
Schools:	Schools > Salford Business School > Salford Business School Research Centre
Journal or Publication Title:	System Dynamics Review
Publisher:	John Wiley & Sons
Refereed:	Yes
ISSN:	1099-1727
Depositing User:	H Kenna
Date Deposited:	22 Aug 2007 10:21
Last Modified:	16 Feb 2022 07:36
URI:	https://usir.salford.ac.uk/id/eprint/288

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