Mekmaysy, C, Petraccome, L, Garbett, N, Ragazzon, PA, Gray, R, Trent, J and Chaires, J 2008, 'Effect of O6-methylguanine on the stability of G-quadruplex DNA' , Journal of the American Chemical Society, 130 (21) , pp. 6710-6711.
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Abstract
The effects of substitution of O6-methylguanine on the structure and stability of a human telomere quadruplex was studied by circular dichroism, thermal denaturation, analytical ultracentrifugation, and molecular dynamics simulations. The results show that, while quadruplex structures can form containing the modified base, they are much less stable than the normal unmodified structure. The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure
Item Type: | Article |
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Themes: | Health and Wellbeing |
Schools: | Schools > School of Environment and Life Sciences > Biomedical Research Centre |
Journal or Publication Title: | Journal of the American Chemical Society |
Publisher: | ACS Publications |
Refereed: | Yes |
ISSN: | 0002-7863 |
Related URLs: | |
Funders: | National Cancel Institute (NCI) |
Depositing User: | PA Ragazzon |
Date Deposited: | 16 Jan 2015 11:51 |
Last Modified: | 23 Dec 2018 17:56 |
URI: | http://usir.salford.ac.uk/id/eprint/33306 |
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