Taking the pseudo out of pseudogenes

Goodhead, IB ORCID: https://orcid.org/0000-0002-3110-9442 and Darby, AC 2015, 'Taking the pseudo out of pseudogenes' , Current Opinion in Microbiology, 23 , pp. 102-109.

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Pseudogenes are defined as fragments of once-functional genes that have been silenced by one or more nonsense, frameshift or missense mutations. Despite continuing increases in the speed of sequencing and annotating bacterial genomes, the identification and categorisation of pseudogenes remains problematic. Even when identified, pseudogenes are considered to be rare and tend to be ignored. On the contrary, pseudogenes are surprisingly prevalent and can persist for long evolutionary time periods, representing a record of once-functional genetic characteristics. Most importantly, pseudogenes provide an insight into prokaryotic evolutionary history as a record of phenotypic traits that have been lost. Focusing on the intracellular and symbiotic bacteria in which pseudogenes predominate, this review discusses the importance of identifying pseudogenes to fully understand the abilities of bacteria, and to understand prokaryotes within their evolutionary context.

Item Type: Article
Themes: Subjects outside of the University Themes
Schools: Schools > School of Environment and Life Sciences > Ecosystems and Environment Research Centre
Journal or Publication Title: Current Opinion in Microbiology
Publisher: Elsevier
Refereed: Yes
ISSN: 1369-5274
Funders: Biotechnology and Biosciences Sciences Research Council (BBSRC)
Depositing User: Dr Ian Goodhead
Date Deposited: 23 Sep 2015 16:57
Last Modified: 16 Feb 2022 17:06
URI: http://usir.salford.ac.uk/id/eprint/36283

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