Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer

Almelah, EBM, Smith, D, McGown, AT, Aziz, A ORCID: https://orcid.org/0000-0002-8774-0348, Potgieter, H and Ragazzon, PA 2016, 'Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer' , Anticancer Research, 36 (11) , pp. 6043-6050.

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Abstract

Abstract. Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We have developed a novel molecule, 2', 4'-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon, lung and osteoblasts cancer cell lines. Thionylation of 2', 4'- dihydroxydibenzoylmethane led to selective targeting of bone cancer cells, stopping their growth and leading to their death without affecting non-cancerous cells within the bone marrow or other non-malignant cells.

Item Type:	Article
Schools:	Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title:	Anticancer Research
Publisher:	International Institute of Anticancer Research (IIAR)
ISSN:	0250-7005
Related URLs:	Publication
Funders:	University of Salford teaching grant
Depositing User:	PA Ragazzon
Date Deposited:	10 May 2016 15:01
Last Modified:	15 Feb 2022 20:46
URI:	https://usir.salford.ac.uk/id/eprint/38925

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