Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques

Latimer, J ORCID: https://orcid.org/0000-0001-9704-0209, Munday, JL, Buzza, KM, Sreenivasan, PK and McBain, AJ 2015, 'Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques' , American Journal of Dentistry, 28 Spe , 9A-13A.

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Abstract

PURPOSE To assess the antimicrobial effects of a fluoride-free and alcohol-free mouthrinse containing 0.075% CPC (test rinse, TR) compared with an otherwise-identical CPC-free control rinse (CR). METHODS Activity against laboratory cultures of Fusobacterium nucleatum, a bacterium associated with gingival disease, was determined using viable counting following 30-second exposures to TR and CR. Effects against intact saliva-derived plaque biofilms were quantified using confocal microscopy coupled with three-dimensional image analyses (viability profiling). RESULTS Short exposures to TR caused significant inactivation of F. nucleatum, as determined by viable counting (c. 3 log reduction compared to the control rinse, P < 0.05). Confocal microscopy revealed extensive inactivation of complex oral biofilms following treatment with TR; biofilms were significantly less viable than those exposed to CR and three-dimensional images revealed extensive zones of dead bacteria even within plaque depths. In conclusion, this investigation demonstrates that the CPC-containing mouthrinse has significant antibacterial efficacy against oral bacteria associated with gingival disease and significantly inactivated plaque biofilm in comparison to a relevant control.

Item Type:	Article
Schools:	Schools > School of Environment and Life Sciences
Journal or Publication Title:	American Journal of Dentistry
Publisher:	Mosher and Linder Inc
ISSN:	0894-8275
Funders:	Colgate Palmolive
Depositing User:	J Latimer
Date Deposited:	24 Oct 2016 10:27
Last Modified:	27 Aug 2021 23:29
URI:	https://usir.salford.ac.uk/id/eprint/39966

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