Zheng, LL, Liao, JY, Wen, YZ, Hide, G ORCID: https://orcid.org/0000-0002-3608-0175, Qu, LH and Lun, ZR
2016,
'Different types of small RNAs in protozoa'
, in:
Non-coding RNAs and inter-kingdom communication
, Springer International Publishing, pp. 177-196.
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Abstract
The origin and evolution of small RNA molecules is a long-standing mystery. The protozoa represent the earliest eukaryotes and encompass rich diverse genetic resources. However, there are many contradictions and disputes prevalent in studies on protozoan microRNAs. In this review, we summarize the research on the analysis of small RNA transcriptome data on two representative protozoans, Trypanosoma brucei and Giardia lamblia , as generated by high throughput sequencing. The results show that these protozoans do not have canonical miRNAs. Unexpectedly, there are many types of endogenous small interfering RNAs (endo-siRNAs). In addition, stress induced tRNA derived small RNAs (sitRNAs) were observed in different life cycle stages of these parasites. In total, there are six kinds of sitRNAs in G. lamblia . These small RNAs are then found to be involved in the differentiation processes of primitive eukaryotes . These results showed that systematic analysis of small RNAs in the protozoa revealed a more complex picture than previously thought
Item Type: | Book Section |
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Editors: | Leitao, AL and Enguita, FJ |
Schools: | Schools > School of Environment and Life Sciences > Biomedical Research Centre Schools > School of Environment and Life Sciences > Ecosystems and Environment Research Centre |
Publisher: | Springer International Publishing |
ISBN: | 9783319394947 |
Related URLs: | |
Depositing User: | Professor Geoff Hide |
Date Deposited: | 02 Mar 2017 11:05 |
Last Modified: | 16 Feb 2022 18:17 |
URI: | https://usir.salford.ac.uk/id/eprint/41528 |
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