Sidhaye, AA, Bhuran, KC, Zambare, S, Abubaker, M, Nirmalan, NJ ORCID: https://orcid.org/0000-0001-9000-298X and Singh, KK
2016,
'Bio-inspired artemether loaded human serum albumin nanoparticles for effective control of malaria-infected erythrocytes'
, Nanomedicine, 11 (21)
, pp. 2809-2828.
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Abstract
Background: The intra-erythrocytic development of the malarial parasite is dependent on active uptake of nutrients, including human serum albumin(HSA), into parasitized erythrocytes(pRBCs). We have designed HSA-based nanoparticles as a potential drugdelivery option for antimalarials. Methods: Artemether-loaded nanoparticles(AAN) were designed and antimalarial activity evaluated in-vitro/in-vivo using Plasmodium falciparum/Plasmodium berghei species, respectively. Results: Selective internalisation of AAN into Plasmodium-infected RBCs in preference to healthy erythrocytes was observed using confocal-imaging. In-vitro studies showed 50% dose reduction for AAN as compared to drug-only controls to achieve IC50 levels of inhibition. The nanoparticles exhibited 2-fold higher peak drug concentrations in RBCs with antimalarial activity at 50% of therapeutic doses in P.bergei-infected mice. Conclusion: HSA-based nanoparticles offer safe and effective approach for selective targeting of antimalarial drugs.
Item Type: | Article |
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Schools: | Schools > School of Environment and Life Sciences |
Journal or Publication Title: | Nanomedicine |
Publisher: | Future Medicine |
ISSN: | 1743-5889 |
Related URLs: | |
Depositing User: | USIR Admin |
Date Deposited: | 05 Jun 2017 08:11 |
Last Modified: | 06 Jan 2021 15:34 |
URI: | http://usir.salford.ac.uk/id/eprint/42497 |
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