Bio-inspired artemether loaded human serum albumin nanoparticles for effective control of malaria-infected erythrocytes

Sidhaye, AA, Bhuran, KC, Zambare, S, Abubaker, M, Nirmalan, NJ ORCID: https://orcid.org/0000-0001-9000-298X and Singh, KK 2016, 'Bio-inspired artemether loaded human serum albumin nanoparticles for effective control of malaria-infected erythrocytes' , Nanomedicine, 11 (21) , pp. 2809-2828.

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Abstract

Background: The intra-erythrocytic development of the malarial parasite is dependent on active uptake of nutrients, including human serum albumin(HSA), into parasitized erythrocytes(pRBCs). We have designed HSA-based nanoparticles as a potential drugdelivery option for antimalarials. Methods: Artemether-loaded nanoparticles(AAN) were designed and antimalarial activity evaluated in-vitro/in-vivo using Plasmodium falciparum/Plasmodium berghei species, respectively. Results: Selective internalisation of AAN into Plasmodium-infected RBCs in preference to healthy erythrocytes was observed using confocal-imaging. In-vitro studies showed 50% dose reduction for AAN as compared to drug-only controls to achieve IC50 levels of inhibition. The nanoparticles exhibited 2-fold higher peak drug concentrations in RBCs with antimalarial activity at 50% of therapeutic doses in P.bergei-infected mice. Conclusion: HSA-based nanoparticles offer safe and effective approach for selective targeting of antimalarial drugs.

Item Type:	Article
Schools:	Schools > School of Environment and Life Sciences
Journal or Publication Title:	Nanomedicine
Publisher:	Future Medicine
ISSN:	1743-5889
Related URLs:	Publication
Depositing User:	USIR Admin
Date Deposited:	05 Jun 2017 08:11
Last Modified:	03 Apr 2020 17:09
URI:	http://usir.salford.ac.uk/id/eprint/42497

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