Role of key players in paradigm shifts of prostate cancer bone metastasis

Sohail, A, Sherin, L, Butt, SI, Javed, S, Li, Z, Iqbal, S and Beg, OA ORCID: https://orcid.org/0000-0001-5925-6711 2018, 'Role of key players in paradigm shifts of prostate cancer bone metastasis' , Cancer Management and Research, 2018 (10) , pp. 1619-1626.

Preview	PDF - Published Version Available under License Creative Commons Attribution Non-commercial. Download (1MB) | Preview
	PDF - Accepted Version Restricted to Repository staff only Download (4MB) | Request a copy

Abstract

Prostate cancer is one of the most common human cancers and bone metastasis is a frequent finding in the natural history of several types of cancers. The molecular mechanisms that makes prostate cancer metastasize to bone have recently been identified, and provide new molecular targets for drug development, several biochemical by-products that provide insight into the tumorbone interaction, with potential to enhance the clinical management of patients with bone metastases, have been reported during the past decade, however, its anticipated risk, diagnosis and response to therapy are still challenging to assess in clinical practice. In this article, we will discuss these challenges with an emphasis on the communication pathways between each cell type involved and the roles of Wnts, sclerostin, RANKL, PTHrP and macrophages.

Item Type:	Article
Schools:	Schools > School of Computing, Science and Engineering
Journal or Publication Title:	Cancer Management and Research
Publisher:	Dove Medical Press
ISSN:	1179-1322
Related URLs:	Publisher
Depositing User:	OA Beg
Date Deposited:	03 Apr 2018 10:07
Last Modified:	24 Jan 2020 08:30
URI:	http://usir.salford.ac.uk/id/eprint/46438

Actions (login required)

Edit record (repository staff only)