Modulation of vascular reactivity by perivascular adipose tissue (PVAT)

Agabiti Rosei, C, Paini, A, De Ciuceis, C, Withers, SB ORCID: https://orcid.org/0000-0002-7021-881X, Greenstein, A, Heagerty, AM and Rizzoni, D 2018, 'Modulation of vascular reactivity by perivascular adipose tissue (PVAT)' , Current Hypertension Reports, 20 (44) .

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Abstract

Purpose of Review: In this review we discuss the role of perivascular adipose tissue (PVAT) in the modulation of vascular contractility and arterial pressure, focusing on the role of the renin-angiotensin-aldosterone system and oxidative stress/inflammation.
Recent Findings: PVAT possesses an relevant endocrine-paracrine activity, which may be altered in several pathophysiological and clinical conditions. During the last two decades it has been shown PVAT may modulate vascular reactivity. It has also been previously demonstrated that inflammation in adipose tissue may be implicated in vascular dysfunction. In particular, adipocytes secrete a number of adipokines with various functions, as well as several vasoactive factors, together with components of the renin-angiotensin system which may act at local or at systemic level. It has been shown that the anticontractile effect of PVAT is lost in obesity, probably as a consequence of the development of adipocyte hypertrophy, inflammation, and oxidative stress.
Summary: Adipose tissue dysfunction is interrelated with inflammation and oxidative stress, thus contributing to endothelial dysfunction observed in several pathological and clinical conditions such as obesity and hypertension. Decreased local adiponectin level, macrophage recruitment and infiltration, and activation of renin-angiotensin-aldosterone system could play an important role in this regards.

Item Type:	Article
Schools:	Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title:	Current Hypertension Reports
Publisher:	Springer
ISSN:	1522-6417
Related URLs:	Publisher
Depositing User:	Sarah Withers
Date Deposited:	03 Apr 2018 15:02
Last Modified:	15 Feb 2022 23:04
URI:	https://usir.salford.ac.uk/id/eprint/46513

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