The efficacy of a lateral wedge insole for painful medial knee osteoarthritis after prescreening : a randomized clinical trial

Felson, DT, Parkes, M, Carter, S, Liu, A ORCID:, Callaghan, MJ, Hodgson, R, Bowes, M and Jones, RK ORCID: 2019, 'The efficacy of a lateral wedge insole for painful medial knee osteoarthritis after prescreening : a randomized clinical trial' , Arthritis & Rheumatology, 71 (6) , pp. 908-915.

PDF - Accepted Version
Download (451kB) | Preview


Lateral wedge shoe insoles decrease medial knee loading, but trials have shown no effect on pain in medial knee osteoarthritis (OA). However, insoles' loading effects are inconsistent, and they can increase patellofemoral loading. We hypothesized that insoles would reduce pain in preselected patients.

In persons with painful medial knee OA, we excluded those with patellofemoral OA and those with pain <4/10. We further excluded participants who, in a gait laboratory using lateral wedges, did not show at least a 2% reduction in knee adduction moment (KAM) compared with their shoes and a neutral insole. We then randomized subjects to lateral wedge vs. neutral insole for 8 week periods separated by an 8 week washout. Primary outcome was knee pain over the past week (0-10) and secondary outcomes nominated activity pain and KOOS pain. We carried out mixed model analyses adjusted for baseline pain.

Of 83 participants, 21 (25%) were excluded because of insufficient reduction in KAM. Of 62 included, mean age was 64.2 years (SD 9.1); 37.1% were women. Lateral wedge insoles produced a greater reduction in knee pain than neutral insoles (difference 0.7 on 0-10 scale; 95%CI 0.1, 1.2; p = 0.02). Secondary outcomes showed mixed findings.

In persons prescreened to eliminate those with patellofemoral OA and biomechanical non-responders, lateral wedge insoles reduced knee pain, but the effect of treatment was small and is likely of clinical significance in only a minority of patients. Targeting patients may identify those who respond to this treatment.

Item Type: Article
Schools: Schools > School of Health and Society > Centre for Health Sciences Research
Journal or Publication Title: Arthritis & Rheumatology
Publisher: Wiley
ISSN: 2326-5191
Related URLs:
Funders: NIHR Manchester Biomedical Research Centre, National Institutes of Health (NIH)
Depositing User: Prof Richard Jones
Date Deposited: 10 Jan 2019 13:46
Last Modified: 16 Feb 2022 00:31

Actions (login required)

Edit record (repository staff only) Edit record (repository staff only)


Downloads per month over past year