Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults

Ossoukhova, A, Owen, LJ ORCID: https://orcid.org/0000-0002-2548-1926, Savage, K, Meyer, M, Ibarra, A, Roller, M, Pipingas, A, Wesnes, K and Scholey, A 2015, 'Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults' , Human Psychopharmacology: Clinical and Experimental, 30 (2) , pp. 108-122.

[img]
Preview
PDF
Download (292kB) | Preview

Abstract

Objective: A ginsenoside-rich extract of American ginseng (Panax quinquefolius L.), CereboostTM, was previously shown to improve working memory and mood in healthy young individuals. The present study represented a partial replication investigating whether these effects extended to healthy middle-aged individuals.
Methods: Fifty-two healthy volunteers (40–60 years old, mean age 51.63) received 200 mg of P. quinquefolius or a matching placebo according to a double-blind, placebo-controlled, balanced, crossover design. The Cognitive Drug Research battery and the Computerised Mental Performance Assessment System were used to evaluate cognitive performance at baseline then 1, 3 and 6 h following treatment. Blood glucose and mood were co-monitored.
Results: Compared with placebo, P. quinquefolius improved cognitive performance on ‘Working Memory’ factor at 3 h. Similar effects were observed in one of the two tasks making up this factor, spatial working memory. There were no significant effects on mood or blood glucose levels.
Conclusions: These data confirm that P. quinquefolius can acutely benefit working memory and extend the age range of this effect to middle-aged individuals. These changes are unlikely to be underpinned by modulation of blood glucose in this population.

Item Type: Article
Schools: Schools > School of Health and Society
Journal or Publication Title: Human Psychopharmacology: Clinical and Experimental
Publisher: Wiley
ISSN: 0885-6222
Related URLs:
Funders: This work was sponsored by a grant from Naturex.
Depositing User: LJ Owen
Date Deposited: 11 Feb 2019 11:25
Last Modified: 01 Aug 2019 14:30
URI: http://usir.salford.ac.uk/id/eprint/49996

Actions (login required)

Edit record (repository staff only) Edit record (repository staff only)

Downloads

Downloads per month over past year