Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue

Saxton, SN, Withers, SB and Heagerty, AM 2019, 'Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue' , Cardiovascular Drugs and Therapy, 33 (2) , pp. 245-259.

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Abstract

Perivascular adipose tissue (PVAT) is no longer recognised as simply a structural support for the vasculature, and we now know that PVAT releases vasoactive factors which modulate vascular function. Since the discovery of this function in 1991, PVAT research is rapidly growing and the importance of PVAT function in disease is becoming increasingly clear. Obesity is associated with a plethora of vascular conditions; therefore, the study of adipocytes and their effects on the vasculature is vital. PVAT contains an adrenergic system including nerves, adrenoceptors and transporters. In obesity, the autonomic nervous system is dysfunctional; therefore, sympathetic innervation of PVAT may be the key mechanistic link between increased adiposity and vascular disease. In addition, not all obese people develop vascular disease, but a common feature amongst those that do appears to be the inflammatory cell population in PVAT. This review will discuss what is known about sympathetic innervation of PVAT, and the links between nerve activation and inflammation in obesity. In addition, we will examine the therapeutic potential of exercise in sympathetic stimulation of adipose tissue.

Item Type: Article
Uncontrolled Keywords: Adipose tissue, Exercise, Inflammation, Obesity, Sympathetic nerves
Schools: Schools > School of Health and Society
Journal or Publication Title: Cardiovascular Drugs and Therapy
Publisher: Springer
ISSN: 1573-7241
Related URLs:
Funders: British Heart Foundation
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 27 Feb 2019 08:54
Last Modified: 04 Jun 2019 10:15
URI: http://usir.salford.ac.uk/id/eprint/50230

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