Hallmarks of the cancer cell of origin : comparisons with "energetic" cancer stem cells (e-CSCs)

Sotgia, F, Fiorillo, M and Lisanti, MP 2019, 'Hallmarks of the cancer cell of origin : comparisons with "energetic" cancer stem cells (e-CSCs)' , Aging, 11 (3) , pp. 1065-1068.

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Here, we discuss the expected hallmark(s) of the cancer cell of origin and how this may be related to a new tumor cell phenotype, namely "energetic" cancer stem cells (e-CSCs). e-CSCs show many features that would be characteristic of the cancer cell of origin, including the over-expression of p21-WAF (CDKN1A), a key marker of senescence. It is tempting to speculate that the cancer cell of origin and e-CSCs are closely related entities. e-CSCs possess a hybrid phenotype, sharing key hallmarks of senescence, "stemness" and cancer. e-CSCs are hyper-proliferative and have elevated mitochondrial metabolism, with an NRF2-mediated anti-oxidant response signature, including glutaredoxin (GLRX) and ALDH3A1 over-expression, possibly related to their escape from senescence. Finally, in e-CSCs, BCAS1 (Breast carcinoma-amplified sequence-1) protein expression was up-regulated by >100-fold. BCAS1 is a candidate oncogene associated with "stemness" and aggressive oncogenic behavior, such as Tamoxifen resistance.

Item Type: Article
Uncontrolled Keywords: anti-oxidant response, cancer cell of origin, cancer stem cells (CSCs), metabolism, senescence, tamoxifen resistance
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Aging
Publisher: Impact Journals
ISSN: 1945-4589
Related URLs:
Funders: Lunella Biotech, Inc
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 01 Mar 2019 09:07
Last Modified: 18 Mar 2019 08:00
URI: http://usir.salford.ac.uk/id/eprint/50251

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