Jozsa, F, Ahmed, M, Baker, RD ORCID: https://orcid.org/0000-0003-3555-3425 and Douek, M
2019,
'Is sentinel node biopsy necessary in the radiologically negative axilla in breast cancer?'
, Breast Cancer Research and Treatment, 177
, pp. 1-4.
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Abstract
Purpose: The steady move towards axillary conservatism in breast cancer is based on studies demonstrating that axillary node clearance affords no survival benefit in a subset of patients with a positive pre-operative axillary ultrasound (AUS). However, less attention has been paid to AUS-negative patients who receive sentinel node biopsy as standard.
Methods: Previously assembled systematic review data was reassessed to evaluate nodal burden amongst patients with breast cancer and a clinically and radiologically negative axilla.
Results: Pooled data from four cohort studies reporting pre-operative axillary ultrasound in 5139 patients with breast cancer show it has a negative predictive rate of 0.951 (95% confidence interval 0.941–0.960).
Conclusions: Reconsidering the use of ultrasound in patients with early breast cancer and non-palpable axillae reveals that sentinel node biopsy itself may represent surgical over-treatment in patients with a negative axillary ultrasound. The implications of this on the future of surgical management of the axilla are discussed.
Item Type: | Article |
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Schools: | Schools > Salford Business School |
Journal or Publication Title: | Breast Cancer Research and Treatment |
Publisher: | Springer |
ISSN: | 0167-6806 |
Related URLs: | |
Depositing User: | Prof Rose Dawn Baker |
Date Deposited: | 03 Jun 2019 13:52 |
Last Modified: | 16 Feb 2022 02:09 |
URI: | http://usir.salford.ac.uk/id/eprint/51468 |
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