Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue

Saxton, SN ORCID: https://orcid.org/0000-0002-3067-1652, Clark, BJ, Withers, SB ORCID: https://orcid.org/0000-0002-7021-881X, Eringa, EC and Heagerty, AM 2019, 'Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue' , Physiological Reviews, 99 (4) , pp. 1701-1763.

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Abstract

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be the inflammatory cell population in adipose tissue. Healthy adipose tissue secretes a number of vasoactive adipokines and anti-inflammatory cytokines, and changes to this secretory profile will contribute to pathogenesis in obesity. In this review, we discuss the links between adipokine dysregulation and the development of hypertension and diabetes and explore the potential for manipulating adipose tissue morphology and its immune cell population to improve cardiovascular health in obesity.

Item Type: Article
Additional Information: ** From Crossref via Jisc Publications Router **Journal IDs: pissn 0031-9333; eissn 1522-1210 **History: issued 01-10-2019; published 01-10-2019
Uncontrolled Keywords: Physiology (medical), Physiology, Molecular Biology, General Medicine
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Physiological Reviews
Publisher: American Physiological Society
ISSN: 1522-1210
Related URLs:
Funders: British Heart Foundation
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 11 Oct 2019 13:40
Last Modified: 22 Jan 2020 10:06
URI: http://usir.salford.ac.uk/id/eprint/52586

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