Bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis

Logan, JMJ ORCID: https://orcid.org/0000-0001-6826-7420, Hall, JL ORCID: https://orcid.org/0000-0001-8040-765X, Chalker, VJ, O’Connell, B ORCID: https://orcid.org/0000-0001-6401-6421 and Birtles, RJ ORCID: https://orcid.org/0000-0002-4216-5044 2019, 'Bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis' , Access Microbiology, 1 (10) .

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Abstract

Introduction.
Bartonella species are increasingly recognized as agents of culture-negative endocarditis. However, to date, almost all human cases have been associated with two members of the genus, Bartonella henselae and Bartonella quintana. B. henselae infections are zoonotic, with domestic cats serving as reservoir hosts for the pathogen. Bartonella clarridgeiae also exploits cats as reservoir hosts, but its zoonotic potential is far less established.
Case presentation.
A 34-year-old male presented with palpitations after a history of aortic incompetence. During surgery for an aortic valve replacement, two vegetations were found on the aortic valve. PCR analysis of the vegetation demonstrated the presence of Bartonella species and so the patient was treated post-operatively with ceftriaxone and doxycycline, making a good recovery. Further PCR-based analysis of the patient’s aortic vegetation confirmed the presence of B. clarridgeiae .
Conclusion.
This report expands the number of Bartonella species associated with endocarditis and provides clear evidence that B. clarridgeiae should be considered a zoonotic pathogen.

Item Type: Article
Additional Information: ** From Crossref via Jisc Publications Router **Journal IDs: eissn 2516-8290 **History: issued 10-10-2019; published 10-10-2019
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Access Microbiology
Publisher: Microbiology Society
ISSN: 2516-8290
Related URLs:
Funders: Public Health England, St James’s Hospital, Department of Clinical Microbiology, Dublin 8, Ireland, School of Science, Engineering and Environment, University of Salford
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 21 Oct 2019 12:34
Last Modified: 03 Jan 2020 10:15
URI: http://usir.salford.ac.uk/id/eprint/52773

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