Thioalbamide, a thioamidated peptide from amycolatopsis alba, affects tumor growth and stemness by inducing metabolic dysfunction and oxidative stress

Frattaruolo, L ORCID: https://orcid.org/0000-0002-7018-8454, Fiorillo, M, Brindisi, M ORCID: https://orcid.org/0000-0002-5022-9642, Curcio, R, Dolce, V, Lacret, R ORCID: https://orcid.org/0000-0003-1135-3891, Truman, AW ORCID: https://orcid.org/0000-0001-5453-7485, Sotgia, F ORCID: https://orcid.org/0000-0003-2826-4529, Lisanti, MP and Cappello, AR 2019, 'Thioalbamide, a thioamidated peptide from amycolatopsis alba, affects tumor growth and stemness by inducing metabolic dysfunction and oxidative stress' , Cells, 8 (11) , e1408.

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Abstract

Thioalbamide, a thioamidated peptide biosynthesized by Amycolatopsis alba, is a thioviridamide-like molecule, and is part of a family of natural products representing a focus of biotechnological and pharmaceutical research in recent years due to their potent anti-proliferative and cytotoxic activities on malignant cells. Despite the high antitumor potential observed at nanomolar concentrations, the mechanisms underlying thioalbamide activity are still not known. In this work, the cellular effects induced by thioalbamide treatment on breast cancer cell lines were evaluated for the first time, highlighting the ability of this microbial natural peptide to induce mitochondrial dysfunction, oxidative stress, and apoptotic cell death. Furthermore, we demonstrate that thioalbamide can inhibit the propagation of cancer stem-like cells, which are strongly dependent on mitochondrial function and are responsible for chemotherapy resistance, metastasis, and tumor recurrence.

Item Type: Article
Additional Information: ** From MDPI via Jisc Publications Router ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ **Journal IDs: eissn 2073-4409 **History: published 08-11-2019; accepted 07-11-2019
Uncontrolled Keywords: thioviridamide-like molecules, RiPPs, natural products, anticancer agent, cancer stem cells
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Cells
Publisher: MDPI
ISSN: 2073-4409
Related URLs:
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 11 Nov 2019 09:55
Last Modified: 30 Jul 2020 08:01
URI: http://usir.salford.ac.uk/id/eprint/53006

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