NIR-to-NIR two-photon excited CaF2:Tm3+,Yb3+ nanoparticles: multifunctional nanoprobes for highly penetrating fluorescence bio-imaging

Martinez Maestro, L ORCID: https://orcid.org/0000-0001-6629-5313, Dong, N, Pedroni, M, Piccinell, F, Conti, G, Sbarbati, A, Ramı´rez-Herna´ ndez, JE, Iglesias-de la Cruz, MC, Sanz-Rodriguez, F, Juarranz, A, Chen, F, Vetrone, F, Capobianco, JA, Garcia Sole, J, Jaque, D, Bettinelli, M and Speghini, A 2011, 'NIR-to-NIR two-photon excited CaF2:Tm3+,Yb3+ nanoparticles: multifunctional nanoprobes for highly penetrating fluorescence bio-imaging' , ACS Nano, 5 (11) , pp. 8665-8671.

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Abstract

In this study, we report on the remarkable two-photon excited fluorescence efficiency in the “biological window” of CaF2:Tm3+,Yb3+ nanoparticles. On the basis of the strong Tm3+ ion emission (at around 800 nm), tissue penetration depths as large as 2 mm have been demonstrated, which are more than 4 times those achievable based on the visible emissions in comparable CaF2:Er3+,Yb3+ nanoparticles. The outstanding penetration depth, together with the fluorescence thermal sensitivity demonstrated here, makes CaF2:Tm3+,Yb3+ nanoparticles ideal candidates as multifunctional nanoprobes for high contrast and highly penetrating in vivo fluorescence imaging applications.

Item Type: Article
Schools: Schools > School of Computing, Science and Engineering
Journal or Publication Title: ACS Nano
Publisher: ACS Publications
ISSN: 1936-0851
Related URLs:
Funders: Universidad Autonoma de Madrid, Comunidad Autonoma de Madrid, Spanish Ministerio de Educacion y Ciencia, Natural Sciences and Engineering Research Council (NSERC) of Canada, Concordia University Research Chairs, Spanish Minsterio de Educaci�on, Fondazione Cariverona (Verona, Italy)
Depositing User: L Martinez Maestro
Date Deposited: 10 Dec 2019 10:45
Last Modified: 03 Jan 2020 15:51
URI: http://usir.salford.ac.uk/id/eprint/53278

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