Fluorescent nanothermometers provide controlled plasmonic-mediated intracellular hyperthermia

Martinez Maestro, L ORCID: https://orcid.org/0000-0001-6629-5313, Haro-Gonzalez, H, Iglesias-de la Cruz, M C, Sanz-Rodriguez, F, Garcia Sole, J and Jaque, D 2013, 'Fluorescent nanothermometers provide controlled plasmonic-mediated intracellular hyperthermia' , Nanomedicine, 8 (3) .

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Abstract

This article demonstrates how controlled hyperthermia at the cellular level can be achieved.The method is based on the simultaneous intracellular incorporation of fluorescence nanothermometers (CdSe quantum dots) and metallic nanoheaters (gold nanorods).Real-time spectral analysis of the quantum dot emission provides a detailed feedback about the intracellular thermal loading caused by gold nanorods excited at the plasmon frequency. Based on this approach, thermal dosimetry is assessed in such a way that the infrared laser (heating) power required to achieve catastrophic intracellular temperature increments in cancer cells is identified.This pure optical method emerges as a new and promising guide for the development of infrared hyperthermia therapies with minimal invasiveness.

Item Type: Article
Schools: Schools > School of Computing, Science and Engineering
Journal or Publication Title: Nanomedicine
Publisher: Future Medicine
ISSN: 1743-5889
Related URLs:
Funders: Universidad Autónoma de Madrid, Comunidad Autónoma de Madrid, Spanish Ministerio de Educación y Ciencia, Malta Consolider-Ingenio 2010, FPI grant by Agencia Canaria de Investigación del Gobierno de Canarias, Caja Madrid Foundation
Depositing User: L Martinez Maestro
Date Deposited: 05 Dec 2019 13:46
Last Modified: 05 Dec 2019 13:46
URI: http://usir.salford.ac.uk/id/eprint/53346

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