CdSe quantum dots for two-photon fluorescence thermal imaging.

Martinez Maestro, L ORCID: https://orcid.org/0000-0001-6629-5313, Martin Rodriguez, E, Sanz Rodriguez, F, Iglesias-de la Cruz, MC, Juarranz, A, Naccache, R, Vetrone, F, Jaque, D, Capobianco, JA and Sole, JG 2010, 'CdSe quantum dots for two-photon fluorescence thermal imaging.' , Nano Letters, 10 (12) , pp. 5109-5115.

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Abstract

The technological development of quantum dots has ushered in a new era in fluorescence bioimaging, which was propelled with the advent of novel multiphoton fluorescence microscopes. Here, the potential use of CdSe quantum dots has been evaluated as fluorescent nanothermometers for two-photon fluorescence microscopy. In addition to the enhancement in spatial resolution inherent to any multiphoton excitation processes, two-photon (near-infrared) excitation leads to a temperature sensitivity of the emission intensity much higher than that achieved under one-photon (visible) excitation. The peak emission wavelength is also temperature sensitive, providing an additional approach for thermal imaging, which is particularly interesting for systems where nanoparticles are not homogeneously dispersed. On the basis of these superior thermal sensitivity properties of the two-photon excited fluorescence, we have demonstrated the ability of CdSe quantum dots to image a temperature gradient artificially created in a biocompatible fluid (phosphate-buffered saline) and also their ability to measure an intracellular temperature increase externally induced in a single living cell.

Item Type: Article
Schools: Schools > School of Computing, Science and Engineering
Journal or Publication Title: Nano Letters
Publisher: ACS Publications
ISSN: 1530-6984
Related URLs:
Funders: Universidad Autónoma de Madrid and Comunidad Autonoma de Madrid, Spanish Ministerio de Educacion y Ciencia, Natural Sciences and Engineering Research Council (NSERC) of Canada, Gouvernement du Québec, Ministère du Développement économique, de l’Innovation et de l’Exportation
Depositing User: L Martinez Maestro
Date Deposited: 03 Dec 2019 16:03
Last Modified: 03 Jan 2020 15:51
URI: http://usir.salford.ac.uk/id/eprint/53361

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