Selistre, LFA, Gonçalves, GH, Vasilceac, FA, da Silva Serrão, PRM, Nakagawa, TH, Petrella, M, Jones, RK 
ORCID: https://orcid.org/0000-0001-5242-185X and Mattiello, SM
2021,
'The relationship between urinary C-Telopeptide fragments of type II collagen, knee joint load, pain, and physical function in individuals with medial knee osteoarthritis'
, Brazilian Journal of Physical Therapy, 25 (1)
, pp. 62-69.
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Abstract
Objective: Considering the osteoarthritis (OA) model that integrates the biological, mechanical, and structural components of the disease, the present study aimed to investigate the association between urinary C-Telopeptide fragments of type II collagen (uCTX-II), knee joint moments, pain, and physical function in individuals with medial knee OA. Methods: Twenty-five subjects radiographically diagnosed with knee OA were recruited. Participants were evaluated through three-dimensional gait analysis, uCTX-II level, the WOMAC pain and physical function scores, and the 40m walk test. The association between these variables was investigated using Pearson´s product-moment correlation, followed by a hierarchical linear regression, controlled by OA severity and body mass index (BMI). Results: No relationship was found between uCTX-II level and knee moments. A significant correlation between uCTX-II level and pain, physical function, and the 40m walk test was found. The hierarchical linear regression controlling for OA severity and BMI showed that uCTX-II level explained 9% of the WOMAC pain score, 27% of the WOMAC physical function score, and 7% of the 40m walk test. Conclusion: Greater uCTX-II level is associated with higher pain and reduced physical function and 40m walk test performance in individuals with medial knee OA.
| Item Type: | Article |
|---|---|
| Schools: | Schools > School of Health and Society > Centre for Health Sciences Research |
| Journal or Publication Title: | Brazilian Journal of Physical Therapy |
| Publisher: | Elsevier |
| ISSN: | 1413-3555 |
| Related URLs: | |
| Depositing User: | Prof Richard Jones |
| Date Deposited: | 03 Mar 2020 08:45 |
| Last Modified: | 16 Feb 2022 04:08 |
| URI: | http://usir.salford.ac.uk/id/eprint/56555 |
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