The relationship between urinary C-Telopeptide fragments of type II collagen, knee joint load, pain, and physical function in individuals with medial knee osteoarthritis

Selistre, LFA, Gonçalves, GH, Vasilceac, FA, da Silva Serrão, PRM, Nakagawa, TH, Petrella, M, Jones, RK ORCID: https://orcid.org/0000-0001-5242-185X and Mattiello, SM 2020, 'The relationship between urinary C-Telopeptide fragments of type II collagen, knee joint load, pain, and physical function in individuals with medial knee osteoarthritis' , Brazilian Journal of Physical Therapy .

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Abstract

Objective: Considering the osteoarthritis (OA) model that integrates the biological, mechanical, and structural components of the disease, the present study aimed to investigate the association between urinary C-Telopeptide fragments of type II collagen (uCTX-II), knee joint moments, pain, and physical function in individuals with medial knee OA. Methods: Twenty-five subjects radiographically diagnosed with knee OA were recruited. Participants were evaluated through three-dimensional gait analysis, uCTX-II level, the WOMAC pain and physical function scores, and the 40m walk test. The association between these variables was investigated using Pearson´s product-moment correlation, followed by a hierarchical linear regression, controlled by OA severity and body mass index (BMI). Results: No relationship was found between uCTX-II level and knee moments. A significant correlation between uCTX-II level and pain, physical function, and the 40m walk test was found. The hierarchical linear regression controlling for OA severity and BMI showed that uCTX-II level explained 9% of the WOMAC pain score, 27% of the WOMAC physical function score, and 7% of the 40m walk test. Conclusion: Greater uCTX-II level is associated with higher pain and reduced physical function and 40m walk test performance in individuals with medial knee OA.

Item Type: Article
Schools: Schools > School of Health and Society > Centre for Health Sciences Research
Journal or Publication Title: Brazilian Journal of Physical Therapy
Publisher: Elsevier
ISSN: 1413-3555
Related URLs:
Depositing User: Prof Richard Jones
Date Deposited: 03 Mar 2020 08:45
Last Modified: 03 Mar 2020 08:45
URI: http://usir.salford.ac.uk/id/eprint/56555

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