Positive association of Cardiovascular Disease (CVD) with chronic exposure to drinking water Arsenic (As) at concentrations below the WHO provisional guideline value : a systematic review and meta-analysis

Xu, L, Mondal, D ORCID: https://orcid.org/0000-0002-5144-626X and Polya, DA 2020, 'Positive association of Cardiovascular Disease (CVD) with chronic exposure to drinking water Arsenic (As) at concentrations below the WHO provisional guideline value : a systematic review and meta-analysis' , International Journal of Environmental Research and Public Health, 17 (7) , p. 2536.

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution 4.0.

Download (783kB) | Preview
[img] Microsoft Word - Accepted Version
Restricted to Repository staff only

Download (2MB) | Request a copy

Abstract

To the best of our knowledge, a dose-response meta-analysis of the relationship between cardiovascular disease (CVD) and arsenic (As) exposure at drinking water As concentrations lower than the WHO provisional guideline value (10 µg/L) has not been published yet. We conducted a systematic review and meta-analyses to estimate the pooled association between the relative risk of each CVD endpoint and low-level As concentration in drinking water both linearly and non-linearly using a random effects dose-response model. In this study, a significant positive association was found between the risks of most CVD outcomes and drinking water As concentration for both linear and non-linear models (p-value for trend < 0.05). Using the preferred linear model, we found significant increased risks of coronary heart disease (CHD) mortality and CVD mortality as well as combined fatal and non-fatal CHD, CVD, carotid atherosclerosis disease and hypertension in those exposed to drinking water with an As concentration of 10 µg/L compared to the referent (drinking water As concentration of 1 µg/L) population. Notwithstanding limitations included, the observed significant increased risks of CVD endpoints arising from As concentrations in drinking water between 1 µg/L and the 10 µg/L suggests further lowering of this guideline value should be considered.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Ecosystems and Environment Research Centre
Journal or Publication Title: International Journal of Environmental Research and Public Health
Publisher: MDPI
ISSN: 1660-4601
Related URLs:
Depositing User: Dr Debapriya Mondal
Date Deposited: 08 Apr 2020 13:03
Last Modified: 09 Apr 2020 11:15
URI: http://usir.salford.ac.uk/id/eprint/56791

Actions (login required)

Edit record (repository staff only) Edit record (repository staff only)

Downloads

Downloads per month over past year