COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

Sargiacomo, C, Sotgia, F and Lisanti, MP 2020, 'COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?' , Aging .

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Abstract

COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family. COVID-19 originated in China and spread world-wide, resulting in the pandemic of 2020. For some reason, COVID-19 shows a considerably higher mortality rate in patients with advanced chronological age. This begs the question as to whether there is a functional association between COVID-19 infection and the process of chronological aging. Two host receptors have been proposed for COVID-19. One is CD26 and the other is ACE-2 (angiotensin-converting enzyme 2). Interestingly, both CD26 and the angiotensin system show associations with senescence. Similarly, two proposed therapeutics for the treatment of COVID-19 infection are Azithromycin and Quercetin, both drugs with significant senolytic activity. Also, Chloroquine-related compounds inhibit the induction of the well-known senescence marker, Beta-galactosidase. Other anti-aging drugs should also be considered, such as Rapamycin and Doxycycline, as they behave as inhibitors of protein synthesis, blocking both SASP and viral replication. Therefore, we wish to speculate that the fight against COVID-19 disease should involve testing the hypothesis that senolytics and other anti-aging drugs may have a prominent role in preventing the transmission of the virus, as well as aid in its treatment. Thus, we propose that new clinical trials may be warranted, as several senolytic and anti-aging therapeutics are existing FDA-approved drugs, with excellent safety profiles, and would be readily available for drug repurposing efforts. As Azithromycin and Doxycycline are both commonly used antibiotics that inhibit viral replication and IL-6 production, we may want to consider this general class of antibiotics that functionally inhibits cellular protein synthesis as a side-effect, for the treatment and prevention of COVID-19 disease.

Item Type: Article
Additional Information: ** From PubMed via Jisc Publications Router **Journal IDs: eissn 1945-4589 **Article IDs: pubmed: 32229706; pii: 103001 **History: accepted 29-03-2020; submitted 20-03-2020
Uncontrolled Keywords: Azithromycin, COVID-19, Doxycycline, Hydroxy-chloroquine, Quercetin, Rapamycin, aging, antibiotic, corona virus, drug repurposing, prevention, senescence, senolytic drug therapy, viral replication
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Aging
Publisher: Impact Journals
ISSN: 1945-4589
Related URLs:
Funders: Lunella Biotech, Inc
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 22 Apr 2020 07:13
Last Modified: 22 Apr 2020 08:00
URI: http://usir.salford.ac.uk/id/eprint/56843

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