Actin and myosin in non-neuronal exocytosis

Miklavc, P ORCID: and Frick, M ORCID: 2020, 'Actin and myosin in non-neuronal exocytosis' , Cells, 9 (6) , e1455.

PDF - Published Version
Available under License Creative Commons Attribution 4.0.

Download (907kB) | Preview


Cellular secretion depends on exocytosis of secretory vesicles and discharge of vesicle contents. Actin and myosin are essential for pre-fusion and post-fusion stages of exocytosis. Secretory vesicles depend on actin for transport to and attachment at the cell cortex during the pre-fusion phase. Actin coats on fused vesicles contribute to stabilization of large vesicles, active vesicle contraction and/or retrieval of excess membrane during the post-fusion phase. Myosin molecular motors complement the role of actin. Myosin V is required for vesicle trafficking and attachment to cortical actin. Myosin I and II members engage in local remodeling of cortical actin to allow vesicles to get access to the plasma membrane for membrane fusion. Myosins stabilize open fusion pores and contribute to anchoring and contraction of actin coats to facilitate vesicle content release. Actin and myosin function in secretion is regulated by a plethora of interacting regulatory lipids and proteins. Some of these processes have been first described in non-neuronal cells and reflect adaptations to exocytosis of large secretory vesicles and/or secretion of bulky vesicle cargoes. Here we collate the current knowledge and highlight the role of actomyosin during distinct phases of exocytosis in an attempt to identify unifying molecular mechanisms in non-neuronal secretory cells.

Item Type: Article
Additional Information: ** From MDPI via Jisc Publications Router ** Licence for this article: **Journal IDs: eissn 2073-4409 **History: published 11-06-2020; accepted 06-06-2020
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Cells
Publisher: MDPI
ISSN: 2073-4409
Related URLs:
Funders: Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 15 Jun 2020 08:06
Last Modified: 28 Aug 2021 12:07

Actions (login required)

Edit record (repository staff only) Edit record (repository staff only)


Downloads per month over past year