FoxP3+ T regulatory cells in cancer : prognostic biomarkers and therapeutic targets

Saleh, R and Elkord, E 2020, 'FoxP3+ T regulatory cells in cancer : prognostic biomarkers and therapeutic targets' , Cancer Letters, 490 , pp. 174-185.

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution 4.0.

Download (3MB) | Preview

Abstract

T Regulatory cells (Tregs) can have both protective and pathological roles. They maintain immune homeostasis and inhibit immune responses in various diseases, including cancer. Proportions of Tregs in the peripheral blood of some cancer patients increase by five-to ten-folds, compared to those in healthy individuals. Tregs contribute to cancer development and progression by suppressing T effector cell functions, thereby compromising tumor killing and promoting tumor growth. Highly immunosuppressive Tregs express upregulated levels of the transcription factor, Forkhead box protein P3 (FoxP3). Elevated levels of FoxP3+ Tregs within the tumor microenvironment (TME) showed a positive correlation with poor prognosis in various cancer patients. Despite the success of immunotherapy, including the use of immune checkpoint inhibitors, a significant proportion of patients show low response rates as a result of primary or acquired resistance against therapy. Some of the mechanisms which underlie the development of therapy resistance are associated with Treg suppressive function. In this review, we describe Treg contribution to cancer development/progression, and the mechanisms of Treg-mediated immunosuppression. We discuss the prognostic significance of FoxP3+ Tregs in different cancers and their potential use as prognostic biomarkers. We also describe potential therapeutic strategies to target Tregs in combination with other types of immunotherapies aiming to overcome tumor resistance and improve clinical outcomes in cancer patients. Overall, understanding the prognostic significance of FoxP3+ Tregs in various cancers and their contribution to therapeutic resistance could help in the development of more effective targeted therapeutic strategies to enhance the clinical outcomes in cancer patients.

Item Type: Article
Additional Information: ** Article version: AM ** From Elsevier via Jisc Publications Router ** Licence for AM version of this article starting on 25-07-2020: http://creativecommons.org/licenses/by/4.0/ **Journal IDs: issn 03043835 **History: issue date 25-07-2020; accepted 16-07-2020
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Cancer Letters
Publisher: Elsevier
ISSN: 0304-3835
Related URLs:
Funders: Qatar Biomedical research Institute, Qatar Foundation, Qatar National Library
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 04 Aug 2020 12:27
Last Modified: 04 Aug 2020 12:30
URI: http://usir.salford.ac.uk/id/eprint/57722

Actions (login required)

Edit record (repository staff only) Edit record (repository staff only)

Downloads

Downloads per month over past year