Chen, K 
ORCID: https://orcid.org/0000-0002-2098-1921, Jiao, X, Ashton, A, Di Rocco, A, Pestell, TG, Sun, Y ORCID: https://orcid.org/0000-0003-4004-9514, Zhao, J, Casimiro, MC, Li, Z, Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382, McCue, PA, Shen, D, Achilefu, S ORCID: https://orcid.org/0000-0002-3133-6717, Rui, H ORCID: https://orcid.org/0000-0002-8778-261X and Pestell, RG ORCID: https://orcid.org/0000-0003-3244-8777
2020,
'The membrane-associated form of cyclin D1 enhances cellular invasion'
, Oncogenesis, 9
, p. 83.
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Abstract
The essential G1-cyclin, CCND1, is a collaborative nuclear oncogene that is frequently overexpressed in cancer. D-type cyclins bind and activate CDK4 and CDK6 thereby contributing to G1–S cell-cycle progression. In addition to the nucleus, herein cyclin D1 was also located in the cytoplasmic membrane. In contrast with the nuclear-localized form of cyclin D1 (cyclin D1NL), the cytoplasmic membrane-localized form of cyclin D1 (cyclin D1MEM) induced transwell migration and the velocity of cellular migration. The cyclin D1MEM was sufficient to induce G1–S cell-cycle progression, cellular proliferation, and colony formation. The cyclin D1MEM was sufficient to induce phosphorylation of the serine threonine kinase Akt (Ser473) and augmented extranuclear localized 17β-estradiol dendrimer conjugate (EDC)-mediated phosphorylation of Akt (Ser473). These studies suggest distinct subcellular compartments of cell cycle proteins may convey distinct functions.
| Item Type: | Article |
|---|---|
| Additional Information: | ** From Springer Nature via Jisc Publications Router ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ **Journal IDs: eissn 2157-9024 **Article IDs: publisher-id: s41389-020-00266-y; manuscript: 266 **History: online 18-09-2020; published_online 18-09-2020; registration 05-09-2020; accepted 02-09-2020; collection 09-2020; rev-recd 22-08-2020; submitted 27-01-2020 |
| Schools: | Schools > School of Environment and Life Sciences |
| Journal or Publication Title: | Oncogenesis |
| Publisher: | Nature Publishing Group UK |
| ISSN: | 2157-9024 |
| Related URLs: | |
| Funders: | U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI), U.S. Department of Defense (United States Department of Defense), U.S. Department of Health & Human Services | National Institutes of Health (NIH), U.S. Department of Health & Human Services | National Institutes of Health (NIH), U.S. Department of Health & Human Services | National Institutes of Health (NIH) |
| SWORD Depositor: | Publications Router |
| Depositing User: | Publications Router |
| Date Deposited: | 21 Sep 2020 09:28 |
| Last Modified: | 16 Feb 2022 05:43 |
| URI: | https://usir.salford.ac.uk/id/eprint/58331 |
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