Validating the use of oral swabs for telomere length assessment in dogs

Dutra, L, Souza, F, Friberg, I, Araújo, M, Vasconcellos, A and Young, RJ ORCID: https://orcid.org/0000-0002-8407-2348 2020, 'Validating the use of oral swabs for telomere length assessment in dogs' , Journal of Veterinary Behavior, 40 , pp. 16-20.

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Abstract

The relative telomere length, a biomarker of cellular aging, can be influenced by the cumulative effects of positive and negative events experienced by an individual. For this reason, it has been used to assess the welfare of nonhuman species. Ensuring an animal's well-being also involves choosing methodologies that will cause either none or minimal disturbance to the subject; however, no studies using noninvasive sampling for measuring relative telomere length in nonhuman species were found. The present study is the first to investigate alternatives of noninvasive sampling for obtaining dogs’ DNA samples for measuring telomeres. Results showed that different tissue samples from the same individual yield comparable telomere length measurements, validating the use of buccal swabs over dried blood spot from dogs. The development of a noninvasive methodology is paramount for the animal welfare evaluation of captive and wild animals without affecting the subject, while at the same time, allowing a frequent data collection and a continuous monitoring of the well-being state.

Item Type: Article
Additional Information: ** From Elsevier via Jisc Publications Router
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Journal of Veterinary Behavior
Publisher: Elsevier
ISSN: 1558-7878
Related URLs:
Funders: Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 04 Dec 2020 11:59
Last Modified: 04 Dec 2020 11:59
URI: http://usir.salford.ac.uk/id/eprint/58454

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