Denning, DW, Kilcoyne, A and Ucer, C 2020, 'Non-infectious status indicated by detectable IgG antibody to SARS-CoV-2' , British Dental Journal, 229 (8) , pp. 521-524.
Full text not available from this repository. (Request a copy)Abstract
A key tenet of protection from infection for dentists is to know who is not infectious. The evidence base regarding protection from respiratory pathogens in dentistry is poor. Those with a positive SARS-CoV-2 IgG antibody are non-infectious (>99% certainty) and can be safely treated with good universal precautions, even for aerosol generating procedures. Viral infectivity with SARS-CoV-2 lasts eight days, unlike viral polymerase chain reaction (PCR) swab tests which can persist for as long as seven weeks. SARS-CoV-2 IgG antibody becomes detectable from 11 days after infection. SARS-CoV-2 IgG antibodies are usually neutralising against the virus and their direct antiviral activity was partially demonstrated in 33,000 patients with COVID-19 treated with convalescent plasma in the USA. So, a positive SARS-CoV-2 IgG antibody is a much more accurate determination of infectiousness than a repeat PCR which is only 70% sensitive. It remains to be seen whether SARS-Cov-2 vaccine responses include protective IgG titres and, once vaccines become widespread, can be used to assist decision-making on appropriate personal protective equipment (PPE) in dentistry.
| Item Type: | Article |
|---|---|
| Additional Information: | ** From PubMed via Jisc Publications Router **Journal IDs: eissn 1476-5373 **Article IDs: pubmed: 33097885; pii: 10.1038/s41415-020-2228-9; pmc: PMC7582419 **History: accepted 23-09-2020; submitted 17-07-2020 |
| Schools: | Schools > School of Health and Society |
| Journal or Publication Title: | British Dental Journal |
| Publisher: | Nature Publishing Group |
| ISSN: | 0007-0610 |
| Related URLs: | |
| SWORD Depositor: | Publications Router |
| Depositing User: | Publications Router |
| Date Deposited: | 21 Jan 2021 10:46 |
| Last Modified: | 27 Aug 2021 21:47 |
| URI: | https://usir.salford.ac.uk/id/eprint/58742 |
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