Hormonal control of metabolism : regulation of plasma glucose

Nirmalan, NJ ORCID: https://orcid.org/0000-0001-9000-298X and Nirmalan, M 2020, 'Hormonal control of metabolism : regulation of plasma glucose' , Anaesthesia & Intensive Care Medicine, 21 (11) , pp. 578-583.

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Abstract

Blood glucose concentrations are required to be maintained within a narrow therapeutic range in order to ensure the normal functioning of the body. This is accomplished through a complex, interactive, finely coordinated neuro-endocrine regulatory process. Hormonal control through the opposing actions of insulin and glucagon secreted by the islet cells of the pancreas serve as the primary response mechanism to avert post-prandial hyperglycaemia and fasting hypoglycaemia. In addition to this basic response, a range of endocrine mediators concurrently intervene, to enable the fine modulation of the process through a range of insulin-dependent and insulin-independent processes, which ultimately achieve glycaemic control by influencing tissue glucose uptake, glycolysis, glycogenesis, glycogenolysis and gluconeogenesis. More recent evidence supports a central, predominantly hypothalamic role initiated through nutrient (glucose, fatty acid) and hormonal (insulin, leptin, glucagon-like peptide-1) stimuli that influences glucose regulation by direct or indirect effects on skeletal muscle glucose uptake, islet cell insulin/glucagon secretion and hepatic glucose production.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Anaesthesia & Intensive Care Medicine
Publisher: Elsevier
ISSN: 1472-0299
Related URLs:
Depositing User: USIR Admin
Date Deposited: 04 Jan 2021 15:55
Last Modified: 04 Jan 2021 15:55
URI: http://usir.salford.ac.uk/id/eprint/59247

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