Saxton, SN, Toms, LK, Aldous, RG, Withers, SB 
ORCID: https://orcid.org/0000-0002-7021-881X, Ohanian, J and Heagerty, AM
2021,
'Restoring perivascular adipose tissue function in obesity using exercise'
, Cardiovascular Drugs and Therapy, 35 (6)
, pp. 1291-1304.
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Abstract
Perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating vascular tone. This effect is mediated via sympathetic nervous stimulation of PVAT by a mechanism which involves noradrenaline uptake through organic cation transporter 3 (OCT3) and β -adrenoceptor-mediated adiponectin release. In obesity, autonomic dysfunction occurs, which may result in a loss of PVAT function and subsequent vascular disease. Accordingly, we have investigated abnormalities in obese PVAT, and the potential for exercise in restoring function. Vascular contractility to electrical field stimulation (EFS) was assessed ex vivo in the presence of pharmacological tools in ±PVAT vessels from obese and exercised obese mice. Immunohistochemistry was used to detect changes in expression of β -adrenoceptors, OCT3 and tumour necrosis factor-α (TNFα) in PVAT. High fat feeding induced hypertension, hyperglycaemia, and hyperinsulinaemia, which was reversed using exercise, independent of weight loss. Obesity induced a loss of the PVAT anti-contractile effect, which could not be restored via β -adrenoceptor activation. Moreover, adiponectin no longer exerts vasodilation. Additionally, exercise reversed PVAT dysfunction in obesity by reducing inflammation of PVAT and increasing β -adrenoceptor and OCT3 expression, which were downregulated in obesity. Furthermore, the vasodilator effects of adiponectin were restored. Loss of neutrally mediated PVAT anti-contractile function in obesity will contribute to the development of hypertension and type II diabetes. Exercise training will restore function and treat the vascular complications of obesity.
| Item Type: | Article |
|---|---|
| Additional Information: | ** From PubMed via Jisc Publications Router **Journal IDs: eissn 1573-7241 **Article IDs: pubmed: 33687595; pii: 10.1007/s10557-020-07136-0 **History: accepted 21-12-2020 |
| Schools: | Schools > School of Environment and Life Sciences > Biomedical Research Centre |
| Journal or Publication Title: | Cardiovascular Drugs and Therapy |
| Publisher: | Springer |
| ISSN: | 0920-3206 |
| Related URLs: | |
| Funders: | British Heart Foundation |
| SWORD Depositor: | Publications Router |
| Depositing User: | Publications Router |
| Date Deposited: | 23 Mar 2021 13:04 |
| Last Modified: | 15 Feb 2022 17:06 |
| URI: | https://usir.salford.ac.uk/id/eprint/59909 |
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