Effectiveness of collaborative care in reducing suicidal ideation : an individual participant data meta-analysis

Grigoroglou, C, van der Feltz-Cornelis, C, Hodkinson, A, Coventry, PA, Zghebi, SS, Kontopantelis, E, Bower, P, Lovell, K, Gilbody, S, Waheed, W, Dickens, C, Archer, JE ORCID: https://orcid.org/0000-0002-9999-082X, Blakemore, A, Adler, DA, Aragones, E, Björkelund, C, Bruce, ML, Buszewicz, M, Carney, RM, Cole, MG, Davidson, KW, Gensichen, J, Grote, NK, Russo, J, Huijbregts, K, Huffman, JC, Menchetti, M, Patel, V, Richards, DA, Rollman, B, Smit, A, Zijlstra-Vlasveld, MC, Wells, KB, Zimmermann, T, Unutzer, J and Panagioti, M 2021, 'Effectiveness of collaborative care in reducing suicidal ideation : an individual participant data meta-analysis' , General hospital psychiatry, 71 , pp. 27-35.

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To assess whether CC is more effective at reducing suicidal ideation in people with depression compared with usual care, and whether study and patient factors moderate treatment effects. We searched Medline, Embase, PubMed, PsycINFO, CINAHL, CENTRAL from inception to March 2020 for Randomised Controlled Trials (RCTs) that compared the effectiveness of CC with usual care in depressed adults, and reported changes in suicidal ideation at 4 to 6 months post-randomisation. Mixed-effects models accounted for clustering of participants within trials and heterogeneity across trials. This study is registered with PROSPERO, CRD42020201747. We extracted data from 28 RCTs (11,165 patients) of 83 eligible studies. We observed a small significant clinical improvement of CC on suicidal ideation, compared with usual care (SMD, -0.11 [95%CI, -0.15 to -0.08]; I , 0·47% [95%CI 0.04% to 4.90%]). CC interventions with a recognised psychological treatment were associated with small reductions in suicidal ideation (SMD, -0.15 [95%CI -0.19 to -0.11]). CC was more effective for reducing suicidal ideation among patients aged over 65 years (SMD, - 0.18 [95%CI -0.25 to -0.11]). Primary care based CC with an embedded psychological intervention is the most effective CC framework for reducing suicidal ideation and older patients may benefit the most. [Abstract copyright: Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.]

Item Type: Article
Additional Information: ** From PubMed via Jisc Publications Router **Journal IDs: eissn 1873-7714 **Article IDs: pubmed: 33915444; pii: S0163-8343(21)00054-2 **History: accepted 18-04-2021; revised 15-04-2021; submitted 02-03-2021
Schools: Schools > School of Health and Society
Journal or Publication Title: General hospital psychiatry
Publisher: Elsevier
ISSN: 0163-8343
Related URLs:
Funders: National Institute of Health Research (NIHR) School for Primary Care Research
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 13 May 2021 07:54
Last Modified: 16 Feb 2022 07:09
URI: https://usir.salford.ac.uk/id/eprint/60270

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